The Bernard Osher Foundation/NCCAM CAM Practitioner Research Career Development Award (K01)

Program Abstract

This funding opportunity announcement (FOA) is designed to support The Cancer Genome Atlas (TCGA) research network. The overall goal of this phase of the TCGA initiative is to provide genome-wide catalogs of genomic alterations in 20-25 different types of human cancer that could be used to identify and accelerate the development of new diagnostic and prognostic markers, new targets for pharmaceutical interventions, and new cancer prevention and treatment strategies. Under this FOA, the NCI solicits applications for two types of centers. (1) Genome Characterization Centers (GCCs); and (2) Genome Data Analysis Centers (GDACs, that must be oriented on one of two permissible types of analytical pipelines). An applicant/institution may submit one application for either type of centers or two applications for two different types (with certain restrictions regarding subtypes of GDACs). GCCs will utilize novel high-throughput, high resolution technologies to comprehensively (i.e., genome-wide) detect genomic, epigenomic and transcriptome aberrations including: alterations in chromosome segment copy numbers, translocations, loss of heterozygosity, altered DNA methylation patterns and changes in gene expression, which may play a role in cancer. GDACs will focus on the integration and analysis of data generated by the GCCs and other TCGA components, development of innovative bioinformatic and computational tools and the performance of advanced bioinformatic analyses including, but not limited to: systems biology approaches to discovery, pathway analysis models, and integrative data analysis methods with accompanying visualization tools to identify complex genomic changes; and integrated cancer biology and translational discovery models that will increase our understanding of cancer as a disease process. Prior contribution to the TCGA Pilot Project is not required and all qualified institutions and individuals are encouraged to apply to this FOA.

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