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Method to Elucidate Molecular Structure from Momentum Transfer Cross Section

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Tech ID:
17-008
Principal Investigator:
Christian Bleiholder
Licensing Manager:
Patents:
  • Pending
Description:

Ion mobility spectrometry-mass spectrometry (IMS-MS) is ideally suited to study co-existing, transient conformations of proteins and their complexes related to diseases because of its high sensitivity and speed of MS analysis.

Many existing results suggest that IMS-MS could accurately elucidate structures for these protein conformations in a high-throughput manner.

The present technology identifies how protein tertiary structures can be determined from IMS-MS data in an automated manner.

Advantages:

  • IMS-MS requires a fraction of sample amounts and time
  • Does not suffer from charge-state dependent protein dynamics in the gas phase
  • Computationally efficient
  • Automatized

Click here to watch an interview with Dr. Bleiholder: https://www.youtube.com/watch?v=G7etpbzsWtg