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Flow-Through Lipid Nanotube Arrays for Structure-Function Studies of Membrane Proteins by Solid State NMR

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Tech ID:
07-043
Principal Investigator:
Timothy Cross
Licensing Manager:
Description:

The proposed invention is a novel solid state NMR based technology that takes advantage of a recent finding that uses Anodic Aluminum Oxide (AAO) nano-porous filters to uniformly align membrane proteins in the NMR spectrometer. The technology is similar to SAR by NMR but is applicable to Membrane Proteins, a class of proteins that accounts for more than 60% of all current drug targets.

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Applications:

  • This novel NMR approach can be applied to all membrane proteins with well-aligned membrane protein samples in bicelles or AAO filters
  • This approach can be used for drug development for all infectious diseases, including Mycobacterium Tuberculosis

Advantages:

  • This NMR technique can be used for target-based screening for membrane proteins
  • Allow pharmaceutical research to identify which protein targets may respond to drugs and which targets are relevant to disease