Flow-Through Lipid Nanotube Arrays for Structure-Function Studies of Membrane Proteins by Solid State NMR
The proposed invention is a novel solid state NMR based technology that takes advantage of a recent finding that uses Anodic Aluminum Oxide (AAO) nano-porous filters to uniformly align membrane proteins in the NMR spectrometer. The technology is similar to SAR by NMR but is applicable to Membrane Proteins, a class of proteins that accounts for more than 60% of all current drug targets.
- This novel NMR approach can be applied to all membrane proteins with well-aligned membrane protein samples in bicelles or AAO filters
- This approach can be used for drug development for all infectious diseases, including Mycobacterium Tuberculosis
- This NMR technique can be used for target-based screening for membrane proteins
- Allow pharmaceutical research to identify which protein targets may respond to drugs and which targets are relevant to disease