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Extracellular Vesical-based Cytokine Storm Therapy

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Tech ID:
21-039
Principal Investigator:
Zucai Suo
Licensing Manager:
Patents:
  • Pending
Description:

A cytokine storm, also called hypercytokinemia, is a life-threatening physiological reaction in humans and other animals in which the immune systems causes an uncontrolled and excessive release of pro-inflammatory cytokines. Although cytokines are part of the body’s normal immune response to infection, their uncontrolled sudden release in large quantities can cause multisystem organ failure and even death. In some severe cases of microbial infection such as the flu virus and COVID-19, cytokine production can increase out of control. This excessive immune response can, in some cases, cause an immune response that can damage internal organs.

CD24 is a protein normally expressed in humans. A modification of CD24, soluble CD24 (CD24Fc), is a biological immunomodulator that may be used for treating hyper-inflammation and cytokine storm conditions. Soluble CD24 has been shown to inhibit secretion of inflammatory cytokines and is involved in clinical trials for reduction of cytokine storm caused by COVID-19 infection.

This invention incorporates the use of exosomes and liposomes as a delivery vehicle for soluble CD24. Exosomes and liposomes are loaded with soluble CD24 using a proprietary process developed by Dr. Suo. This process results in high levels of compounds incorporated on the surface and interior of exosomes and liposomes. The exosomes and liposomes protect the compounds until they are delivered to the appropriate target.