Fusicoccane Derivatives and Methods
- Patent pending
Fusicoccanes are a family of natural products containing a characteristic 5-8-5 carbocyclic nucleus. Certain of these natural products, namely fusicoccin (FC) and cotylenin (CN), have attracted considerable interest for their anticancer activity. These molecules cooperate with the cytokine interferon-alpha to induce apoptosis in cancer cells with negligible toxicity to healthy cells.
Professor Frederich and his team have developed a short and flexible photochemical process to prepare the core of these diterpenes and a range of non-natural variants. This synthetic chemistry provides direct access to functional structures with valuable applications in biomedical research and drug development.
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