Identifying Cell and Disease-Specific Replication Timing Signatures
Methods for identifying and classifying differences between biological samples are based on replication timing data. By comparing replication timing data for a test sample(s) to replication timing data for already characterized samples, one can identify differences and profile any new cell type or disease including various cancers. These new methods allow for detection of all the changes between distinct samples, many of which would escape detection by previous methods that discard any features showing any intra-sample variation. This method also has the ability to use replication timing to identify novel biomarkers not detected by other methods.