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Repetitive DNA Elements to Evaluate Genomic Variations

Tech ID:
Principal Investigator:
Alan Lemmon
Licensing Manager:
  • 17/090,454

A unique combination of steps in laboratory protocol that allow simultaneous enrichment (amplification) of thousands of genomic DNA regions that are sequenced and assessed for genetic variants.  Steps include; ligation of a common DNA adapter to fragments of DNA, a Polymerase Chain Reaction, a sequence of computational steps for identifying and profiling sequence data, and a modification of the protocol that utilizes a DNA circularization step to allow larger regions to be enriched that cover upstream and downstream of the repeat motif.