Transcranial Stimulation to Treat DMN Dysfunction

This technology is directly applied to people with mild cognitive impairment and Alzheimer’s disease to alleviate symptoms and improve life quality. It builds upon non-invasive brain stimulation (NIBS), specifically transcranial alternating current stimulation (tACS) that applies a relatively low-intensity sinusoid current through the scalp to stimulate the brain. It targets a major neural network (the default mode network/DMN), which breaks down with normal aging, precipitously in mild cognitive impairment and severely in Alzheimer’s disease.  The application is non-invasive, safe, and user-friendly and has a strong potential to be applied as therapeutics and prophylactics for cognitive impairment and dementia.