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Transcranial Stimulation to Treat DMN Dysfunction

Tech ID:
Principal Investigator:
Wen Li
Licensing Manager:
  • 63/305,158

This technology is directly applied to people with mild cognitive impairment and Alzheimer’s disease to alleviate symptoms and improve life quality. It builds upon non-invasive brain stimulation (NIBS), specifically transcranial alternating current stimulation (tACS) that applies a relatively low-intensity sinusoid current through the scalp to stimulate the brain. It targets a major neural network (the default mode network/DMN), which breaks down with normal aging, precipitously in mild cognitive impairment and severely in Alzheimer’s disease.  The application is non-invasive, safe, and user-friendly and has a strong potential to be applied as therapeutics and prophylactics for cognitive impairment and dementia.