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Chemicals & Pharma

Name Investigator Tech ID Licensing Manager Name Micensing Manager Email Description Tags
Polyelectrolyte Drying Agents Dr. Joseph Schlenoff 21-026 Garrett Edmunds gedmunds@fsu.edu <p><span>This novel anhydrous polyelectrolyte complex can be used as an effective drying agent for removing water from solvents and gases. It can be reactivated at low temperatures, Drying agents, including calcium sulfate, molecular sieves, silica gel, and more, are often used in industrial applications to remove water from liquids and gases where moisture-control is important. Many industrial drying agents can reversibly absorb water, meaning they can be “reactivated” through heating under a vacuum. Often, the temperatures – and, therefore, energy – required to reactivate these drying agents are high, in excess of 200 °C or 300 °C. The present invention is a polyelectrolyte complex (PEC) and is an effective drying agent, performing as well as commonly available agents such as molecular sieves and Drierite in acetonitrile, tetrahydrofuran, and toluene. PEC can be regenerated at lower temperatures, with complete water loss at about 120 °C, and is stable up to 400 °C. PEC is made of positively- and negative-charged polymers and is easily synthesized from readily available, low-cost starting materials.</span></p> <p><span>Key Words :polymers, environmental remediation, drying agent, desiccant, polyelectrolyte</span></p>
Single-Ion Conductor for Li-ion Batteries Dr. Justin Kennemur and Dr. Daniel Hallinan 22-003 Garrett Edmunds gedmunds@fsu.edu <p><span>The present invention is a blend of a low molecular weight polymer with polyelectrolyte polymer having a precisely fixed anionic motif. This material can be used as to create efficient, highly conductive solid-state batteries with low internal resistance. Solid Polymer Electrolytes (SPEs) are materials that can be used to replace the reactive organic solvents used in lithium-ion batteries. SPEs have drawbacks which prevent its wide adoption, such as low comparative conductivities and propensity to develop shorts. Single Ion Conductors (SICs) can overcome these issues by anchoring the negatively charge ion and allowing only the positively charged ion – typically Lithium ions – the mobility to carry the charge. The present material precisely controls the spacing of the negative ions on the polymer background. This material shows excellent ionic conductivity and has transference near unity.</span></p> <p> </p> <p><span>Key Words : Polymers, Energy Storage, Li-ion battery, solid-state conductor, single-ion </span>conductor</p>
Photochemical Synthesis of Polyaromatic Hydrocarbons (PAHs) for Modern Next-gen Electronic Display Dr. Igor Alabugin 22-007 Garrett Edmunds gedmunds@fsu.edu <p><span>Pyrene and its derivatives are Polyaromatic Hydrocarbons (PAHs) that found uses in organic electronic devices such as OLEDs, OFETs, and OPVs due to their high fluorescence quantum yields and inherent deep-blue emission. New synthetic strategies are essential for selective functionalization of the pyrene core and modular control of its physical properties. In this work, we have developed a new strategy for the synthesis of unsymmetrical pyrenes and higher order PAHs via a one-pot double photocyclization sequence of simple and readily available starting materials. In the first part, we describe the development and optimization of this one-pot process to synthesize different unsymmetrical pyrenes containing functional groups of different donor and acceptor ability. The second part expands this new approach to the synthesis of higher order PAHs.</span></p> <p> </p> <p><span>Key Words : LEDs, Chemical Synthesis, Flexible Displays</span></p>
Site-Specific Alkene Hydromethylation via Protonolysis of Titanacyclobutanes Dr. James Frederich 22-002 Garrett Edmunds gedmunds@fsu.edu <p><span>Methyl groups are ubiquitous in biologically active molecules. Thus, new tactics to introduce this alkyl fragment into polyfunctional structures are of significant interest. With this goal in mind, a direct method for the Markovnikov hydromethylation of alkenes was developed by FSU researchers. This method exploits the degenerate metathesis reaction between the titanium methylidene unveiled from Cp2Ti(µ-Cl)(µ-CH2)AlMe2 (Tebbe’s reagent) and unactivated alkenes. Protonolysis of the resulting titanacyclobutanes in situ effects hydromethylation in a chemo-, regio-, and site-selective manner. The broad utility of this method is demonstrated across a series of mono and di-substituted alkenes containing pendant alcohols, ethers, amides, carbamates, and basic amines.</span></p> <p> </p> <p><span>Key Words : Chemical Synthesis</span></p>
LEDs from Metal Halide Perovskites Dr. Biwu Ma 18-034 Garrett Edmunds gedmunds@fsu.edu <p><span>Metal halide perovskites have emerged as a new class of low-cost solution processable semiconductor materials with applications in a variety of optoelectronic devices, from photovoltaics, to photodetectors, lasers, and light emitting diodes (LEDs). Efficient electrically driven LEDs with green light emission based on lead bromide perovskites, such as MAPbBr3 and CsPbBr3 have been achieved. While electrically driven perovskite LEDs have shown great promise with the device efficiency approaching to those of organic and quantum dot LEDs, a number of challenges, such as long-term stability and color tunability, remain to be addressed before the consideration of commercialization. For full-color display and solid-state lighting applications, highly efficient blue and red LEDs are required in addition to green ones, which however have yet achieved comparable device performance for perovskites-based devices. To implement red perovskite LEDs, two major strategies have been attempted to date, one relying on mixing halide, and the other involving the control of quantum well structures. Mixing halide has been shown to enable precise color tuning of photoluminescence and electroluminescence of perovskite LEDs. However, mixed halide perovskites show relatively low photoluminescence quantum efficiency. More critically, mixed-halide perovskites suffer from low spectral stability due to ion migration and phase separation under illumination and electric field. the change of electroluminescence color during the device operation has been observed in all LEDs based on mixed-halide perovskites. In this invention disclosure, we report bright and efficient red perovskites LEDs with great spectral stability by using quasi-2D halide perovskites/polymer (i.e. PEO, PVK, PIP, etc.) composite thin films as the light-emitting layer. By controlling the molar ratios of large organic salt (i.e. benzyl ammonium iodide, phenethylammonium iodide, butylammonium iodie, etc.) and inorganic salts (Csl and Pbl2), FSU researchers have been able to obtain luminescent quasi-2D perovskite thin films with tunable colors from red peaked at 615 nm to deep red peaked at 676 nm. The perovskites/polymer composite approach enables quasi-2D perovskite/PEO composite thin films to possess much higher photoluminescence quantum efficiencies and smoothness than their neat quasi-2D perovskite counterparts. Advantages include: 1. These quasi-2D halide perovskites/polymer composite thin films have high photoluminescence quantum efficiency and superior thin film morpology. 2. Electrically driven LEDs with tunable emissions based on quasi-2D halide perovskites/polymer composite thin films have been achieved with superior device performance. 3. These devices show exceptional EL spectra stability and device performance stability.</span></p> <p> </p> <p><span>Key Words : Chemical Synthesis, LEDs, Perovskites</span></p>
Extracellular Vesical-based Cytokine Storm Therapy Zucai Suo 21-039 Brent Edington bedington@fsu.edu <p>A cytokine storm, also called hypercytokinemia, is a life-threatening physiological reaction in humans and other animals in which the immune systems causes an uncontrolled and excessive release of pro-inflammatory cytokines. Although cytokines are part of the body’s normal immune response to infection, their uncontrolled sudden release in large quantities can cause multisystem organ failure and even death. In some severe cases of microbial infection such as the flu virus and COVID-19, cytokine production can increase out of control. This excessive immune response can, in some cases, cause an immune response that can damage internal organs.</p> <p>CD24 is a protein normally expressed in humans. A modification of CD24, soluble CD24 (CD24Fc), is a biological immunomodulator that may be used for treating hyper-inflammation and cytokine storm conditions. Soluble CD24 has been shown to inhibit secretion of inflammatory cytokines and is involved in clinical trials for reduction of cytokine storm caused by COVID-19 infection.</p> <p>This invention incorporates the use of exosomes and liposomes as a delivery vehicle for soluble CD24. Exosomes and liposomes are loaded with soluble CD24 using a proprietary process developed by Dr. Suo. This process results in high levels of compounds incorporated on the surface and interior of exosomes and liposomes. The exosomes and liposomes protect the compounds until they are delivered to the appropriate target.</p>